Expanding the clinical and phenotypic heterogeneity associated with biallelic variants in ACO2

OBJECTIVE: We describe the clinical characteristics and genetic etiology of several new cases within the ACO2‐related disease spectrum. Mitochondrial aconitase (ACO2) is a nuclear‐encoded tricarboxylic acid cycle enzyme. Homozygous pathogenic missense variants in the ACO2 gene were initially associa...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackburn, Patrick R., Schultz, Matthew J., Lahner, Carrie A., Li, Dong, Bhoj, Elizabeth, Fisher, Laura J., Renaud, Deborah L., Kenney, Amy, Ibrahim, Niema, Hashem, Mais, Zain Seidahmed, Mohammed, Hasadsri, Linda, Schrier Vergano, Samantha A., Alkuraya, Fowzan S., Lanpher, Brendan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318087/
https://www.ncbi.nlm.nih.gov/pubmed/32519519
http://dx.doi.org/10.1002/acn3.51074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318087/
https://www.ncbi.nlm.nih.gov/pubmed/32519519
http://dx.doi.org/10.1002/acn3.51074

Ejemplares similares