Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition

OBJECTIVE: The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy. Perampanel (PER) is a non‐competitive AMPAR antagonist, and pre‐clinical studies have shown the AMPAR‐mediated anticonvulsant e...

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Detalles Bibliográficos
Autores principales: Wright, Sukhvir K., Wilson, Max A., Walsh, Richard, Lo, William B., Mundil, Nilesh, Agrawal, Shakti, Philip, Sunny, Seri, Stefano, Greenhill, Stuart D., Woodhall, Gavin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318092/
https://www.ncbi.nlm.nih.gov/pubmed/32426918
http://dx.doi.org/10.1002/acn3.51030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318092/
https://www.ncbi.nlm.nih.gov/pubmed/32426918
http://dx.doi.org/10.1002/acn3.51030

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