Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway

BACKGROUND: GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells, exosomes can partially reproduce the reparative properties of their parental...

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Detalles Bibliográficos
Autores principales: Hao, Chunshu, Lu, Zhengri, Zhao, Yuanyuan, Chen, Zhong, Shen, Chengxing, Ma, Genshan, Chen, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318537/
https://www.ncbi.nlm.nih.gov/pubmed/32586406
http://dx.doi.org/10.1186/s13287-020-01759-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318537/
https://www.ncbi.nlm.nih.gov/pubmed/32586406
http://dx.doi.org/10.1186/s13287-020-01759-8

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