Blockade of the costimulatory CD28‐B7 family signal axis enables repeated application of AAV8 gene vectors

Adeno‐associated virus serotype 8 (AAV8) gene therapy has shown efficacy in several clinical trials and is considered a highly promising technology to treat monogenic diseases such as hemophilia A and B. However, a major drawback of AAV8 gene therapy is that it can be applied only once because anti‐...

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Detalles Bibliográficos
Autores principales: Frentsch, Marco, Japp, Alberto Sada, Dingeldey, Manuela, Matzmohr, Nadine, Thiel, Andreas, Scheiflinger, Friedrich, Reipert, Birgit M., de la Rosa, Maurus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
HAEMOSTASIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318590/
https://www.ncbi.nlm.nih.gov/pubmed/32011092
http://dx.doi.org/10.1111/jth.14757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318590/
https://www.ncbi.nlm.nih.gov/pubmed/32011092
http://dx.doi.org/10.1111/jth.14757

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