Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

A spider‐transmitted fungus (Rhizopus microsporus) that was isolated from necrotic human tissue was found to harbor endofungal bacteria (Burkholderia sp.). Metabolic profiling of the symbionts revealed a complex of cytotoxic agents (necroximes). Their structures were characterized as oxime‐substitut...

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Detalles Bibliográficos
Autores principales: Niehs, Sarah P., Dose, Benjamin, Richter, Sophie, Pidot, Sacha J., Dahse, Hans‐Martin, Stinear, Timothy P., Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318616/
https://www.ncbi.nlm.nih.gov/pubmed/32040253
http://dx.doi.org/10.1002/anie.201916007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318616/
https://www.ncbi.nlm.nih.gov/pubmed/32040253
http://dx.doi.org/10.1002/anie.201916007

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