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Synthesis and Characterization of Telmisartan‐Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia

New strategies to eradicate cancer stem cells in chronic myeloid leukemia (CML) include a combination of imatinib with peroxisome proliferator‐activated receptor gamma (PPARγ) ligands. Recently, we identified the partial PPARγ agonist telmisartan as effective sensitizer of resistant K562 CML cells t...

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Detalles Bibliográficos
Autores principales: Schoepf, Anna M., Salcher, Stefan, Hohn, Verena, Veider, Florina, Obexer, Petra, Gust, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318623/
https://www.ncbi.nlm.nih.gov/pubmed/32298535
http://dx.doi.org/10.1002/cmdc.202000092