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Stiff‐Stilbene Ligands Target G‐Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

G‐quadruplex nucleic acid structures have long been studied as anticancer targets whilst their potential in antiparasitic therapy has only recently been recognized and barely explored. Herein, we report the synthesis, biophysical characterization, and in vitro screening of a series of stiff‐stilbene...

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Detalles Bibliográficos
Autores principales: O'Hagan, Michael P., Peñalver, Pablo, Gibson, Rosina S. L., Morales, Juan C., Galan, M. Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318697/
https://www.ncbi.nlm.nih.gov/pubmed/32030823
http://dx.doi.org/10.1002/chem.201905753