Cargando…

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crosstalk is lacking. Here, we developed a systematic appr...

Descripción completa

Detalles Bibliográficos
Autores principales: Konrath, Fabian, Mittermeier, Anna, Cristiano, Elena, Wolf, Jana, Loewer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319280/
https://www.ncbi.nlm.nih.gov/pubmed/32589666
http://dx.doi.org/10.1371/journal.pcbi.1007901