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SPEED2: inferring upstream pathway activity from differential gene expression

Extracting signalling pathway activities from transcriptome data is important to infer mechanistic origins of transcriptomic dysregulation, for example in disease. A popular method to do so is by enrichment analysis of signature genes in e.g. differentially regulated genes. Previously, we derived si...

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Detalles Bibliográficos
Autores principales: Rydenfelt, Mattias, Klinger, Bertram, Klünemann, Martina, Blüthgen, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319438/
https://www.ncbi.nlm.nih.gov/pubmed/32313938
http://dx.doi.org/10.1093/nar/gkaa236