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mmCSM-AB: guiding rational antibody engineering through multiple point mutations

While antibodies are becoming an increasingly important therapeutic class, especially in personalized medicine, their development and optimization has been largely through experimental exploration. While there have been many efforts to develop computational tools to guide rational antibody engineeri...

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Detalles Bibliográficos
Autores principales: Myung, Yoochan, Pires, Douglas E V, Ascher, David B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319589/
https://www.ncbi.nlm.nih.gov/pubmed/32432715
http://dx.doi.org/10.1093/nar/gkaa389