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Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay

Class 1 histone deacetylases (HDACs) like RpdA have gained importance as potential targets for treatment of fungal infections and for genome mining of fungal secondary metabolites. Inhibitor screening, however, requires purified enzyme activities. Since class 1 deacetylases exert their function as m...

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Detalles Bibliográficos
Autores principales: Bauer, Ingo, Pidroni, Angelo, Bayram, Özgür, Brosch, Gerald, Graessle, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319801/
https://www.ncbi.nlm.nih.gov/pubmed/31107465
http://dx.doi.org/10.3791/59527