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Focus on the spectra that matter by clustering of quantification data in shotgun proteomics

In shotgun proteomics, the analysis of label-free quantification experiments is typically limited by the identification rate and the noise level in the quantitative data. This generally causes a low sensitivity in differential expression analysis. Here, we propose a quantification-first approach for...

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Detalles Bibliográficos
Autores principales: The, Matthew, Käll, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319958/
https://www.ncbi.nlm.nih.gov/pubmed/32591519
http://dx.doi.org/10.1038/s41467-020-17037-3