Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug discovery. Here, we explored autophagy as a mechanism...

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Detalles Bibliográficos
Autores principales: Silva, M. Catarina, Nandi, Ghata A., Tentarelli, Sharon, Gurrell, Ian K., Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C., Brown, Dean G., Brandon, Nicholas J., Haggarty, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320012/
https://www.ncbi.nlm.nih.gov/pubmed/32591533
http://dx.doi.org/10.1038/s41467-020-16984-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320012/
https://www.ncbi.nlm.nih.gov/pubmed/32591533
http://dx.doi.org/10.1038/s41467-020-16984-1

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