Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

Process intensification strategies are needed in the field of therapeutic protein production for higher productivities, lower cost of goods and improved facility utilization. This work describes an intensification approach, which connects a tangential-flow-filtration (TFF) based pre-stage perfusion...

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Detalles Bibliográficos
Autores principales: Stepper, Lisa, Filser, Florian Alois, Fischer, Simon, Schaub, Jochen, Gorr, Ingo, Voges, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320070/
https://www.ncbi.nlm.nih.gov/pubmed/32266469
http://dx.doi.org/10.1007/s00449-020-02337-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320070/
https://www.ncbi.nlm.nih.gov/pubmed/32266469
http://dx.doi.org/10.1007/s00449-020-02337-1

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