Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC. Targeted disruption of SMS in CRC c...

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Detalles Bibliográficos
Autores principales: Guo, Yubin, Ye, Qing, Deng, Pan, Cao, Yanan, He, Daheng, Zhou, Zhaohe, Wang, Chi, Zaytseva, Yekaterina Y., Schwartz, Charles E., Lee, Eun Y., Evers, B. Mark, Morris, Andrew J., Liu, Side, She, Qing-Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320137/
https://www.ncbi.nlm.nih.gov/pubmed/32591507
http://dx.doi.org/10.1038/s41467-020-17067-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320137/
https://www.ncbi.nlm.nih.gov/pubmed/32591507
http://dx.doi.org/10.1038/s41467-020-17067-x

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