Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodo...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Tuo, Cheng, Qiang, Min, Yi-Li, Olson, Eric N., Siegwart, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320157/
https://www.ncbi.nlm.nih.gov/pubmed/32591530
http://dx.doi.org/10.1038/s41467-020-17029-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320157/
https://www.ncbi.nlm.nih.gov/pubmed/32591530
http://dx.doi.org/10.1038/s41467-020-17029-3

Ejemplares similares