Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences between cancer and normal tissues for clinical use has been challenging. Here we describe the clinical translation of ONM-100, a nanoparticle-based fluorescent i...

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Detalles Bibliográficos
Autores principales: Voskuil, F. J., Steinkamp, P. J., Zhao, T., van der Vegt, B., Koller, M., Doff, J. J., Jayalakshmi, Y., Hartung, J. P., Gao, J., Sumer, B. D., Witjes, M. J. H., van Dam, G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320194/
https://www.ncbi.nlm.nih.gov/pubmed/32591522
http://dx.doi.org/10.1038/s41467-020-16814-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320194/
https://www.ncbi.nlm.nih.gov/pubmed/32591522
http://dx.doi.org/10.1038/s41467-020-16814-4

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