Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciens

Demecycline (DMTC) and demeclocycline (DMCTC) are C6-demethylated derivatives of tetracycline (TC) and chlortetracycline (CTC), respectively. They are precursors of minocycline and tigecycline, which showed remarkable bioactivity against TC-resistant bacteria and have been used clinically for decade...

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Detalles Bibliográficos
Autores principales: Yang, Weinan, Kong, Lingxin, Wang, Qing, Deng, Zixin, You, Delin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320239/
https://www.ncbi.nlm.nih.gov/pubmed/32637665
http://dx.doi.org/10.1016/j.synbio.2020.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320239/
https://www.ncbi.nlm.nih.gov/pubmed/32637665
http://dx.doi.org/10.1016/j.synbio.2020.06.001

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