Cargando…

Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis

PURPOSE: Osteosarcoma (OS) is the most common primary malignant tumor of the bone in young adolescents and children. We explored the underlying mechanism of Aurora-B in promoting OS cell proliferation and metastasis. PATIENT AND METHODS: Bioinformatics was employed to predict the substrate of Aurora...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Honghai, Zhou, Yang, Peng, Aifen, Liu, Jiaming, Wu, Xin, Chen, Wenzhao, Liu, Zhili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320907/ https://www.ncbi.nlm.nih.gov/pubmed/32606971 http://dx.doi.org/10.2147/CMAR.S252847

Ejemplares similares

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
por: Cheng, Hsin-Lin, et al.
Publicado: (2016)

Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents
por: Linder, Thomas, et al.
Publicado: (2021)

Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
por: Mostafa, Rasha E., et al.
Publicado: (2023)

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes
por: Suryavanshi, Sachin V., et al.
Publicado: (2017)

Anoikis resistant mediated by FASN promoted growth and metastasis of osteosarcoma
por: Sun, Tianhao, et al.
Publicado: (2019)

Let-7a inhibits osteosarcoma cell growth and lung metastasis by targeting Aurora-B
por: Yu, Jing-Jing, et al.
Publicado: (2018)

MicroRNAs in the Regulation of MMPs and Metastasis
por: Abba, Mohammed, et al.
Publicado: (2014)

Knockdown of NIK and IKKβ-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-κΒ Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK
por: Qin, Mengbin, et al.
Publicado: (2017)

3D micro-environment regulates NF-κβ dependent adhesion to induce monocyte differentiation
por: Bhattacharya, Anindita, et al.
Publicado: (2018)

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2017)

Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3
por: Abdel-Wahab, Basel A., et al.
Publicado: (2014)

MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition
por: Fujikura, Tomoyuki, et al.
Publicado: (2018)

Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin
por: Khalil, Mohammed N. A., et al.
Publicado: (2019)

1-Methyl-D-tryptophan Reduces Tumor CD133(+) cells, Wnt/β-catenin and NF-κβp65 while Enhances Lymphocytes NF-κβ2, STAT3, and STAT4 Pathways in Murine Pancreatic Adenocarcinoma
por: Alahdal, Murad, et al.
Publicado: (2018)

Metastasis-associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c-Jun/MMPs pathway
por: Su, Zexin, et al.
Publicado: (2020)

Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells
por: Shi, Guiling, et al.
Publicado: (2017)

Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ
por: Hwang, Soonjae, et al.
Publicado: (2019)

Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway
por: Salama, Abeer, et al.
Publicado: (2021)

Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro
por: Chung, Connie, et al.
Publicado: (2021)

Author Correction: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2018)

Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway
por: Wu, Xin, et al.
Publicado: (2020)

Protective Effects of Bisoprolol Against Cadmium-induced Myocardial Toxicity Through Inhibition of Oxidative Stress and NF-κΒ Signalling in Rats
por: Liu, Jinhua, et al.
Publicado: (2021)

Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial-mesenchymal transition mediated by the FAK/AKT/MMPs axis
por: Liu, Shi-Quan, et al.
Publicado: (2018)

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
por: Marazioti, Antonia, et al.
Publicado: (2018)

Regulation of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κβ) in Inflammatory Bowel Diseases
por: Zaidi, Deenaz, et al.
Publicado: (2018)

Altered Adhesion and Migration of Human Mesenchymal Stromal Cells under Febrile Temperature Stress Involves NF-κβ Pathway
por: Sen, Ankita, et al.
Publicado: (2020)

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats
por: Othman, Zaidatul Akmal, et al.
Publicado: (2022)

Rosemarinic acid protects β-cell from STZ-induced cell damage via modulating NF-κβ pathway
por: El-Huneidi, Waseem, et al.
Publicado: (2023)

Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
por: Tsai, Jong-Rung, et al.
Publicado: (2015)

Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis
por: Lv, Yaqi, et al.
Publicado: (2018)

Inhibition of Aurora-B suppresses osteosarcoma cell migration and invasion
por: ZHU, XIAO PING, et al.
Publicado: (2014)

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma
por: Tavanti, E, et al.
Publicado: (2013)

Differential expression in genes involved in the NF-κβ pathway among asymptomatic HTLV-1 carriers and HAM/TSP patients in Peru
por: Talledo, Michael, et al.
Publicado: (2014)

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway
por: Arenas, Yaiza M., et al.
Publicado: (2020)

Cardamonin Exerts Antitumor Effect on Human Hepatocellular Carcinoma Xenografts in Athymic Nude Mice through Inhibiting NF-κβ Pathway
por: Badroon, Nassrin, et al.
Publicado: (2020)

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
por: Zhao, Hengfang, et al.
Publicado: (2021)

Matrix Metalloproteinases (MMPs) and Inhibitors of MMPs in the Avian Reproductive System: An Overview
por: Hrabia, Anna
Publicado: (2021)

MMPs rearrange DNA
por: LeBrasseur, Nicole
Publicado: (2005)

Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway
por: Triantafyllou, Eleni-Anastasia, et al.
Publicado: (2019)

FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway
por: Zheng, Pengchao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2tv2b19697lmcr4f92cluc3cng