Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity

A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d with aldehydes 2–5 using mild reaction condition with a good yield percentage. The chemical structure of newly formed Schif...

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Detalles Bibliográficos
Autores principales: Hassan, Ashraf S., Askar, Ahmed A., Naglah, Ahmed M., Almehizia, Abdulrahman A., Ragab, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321065/
https://www.ncbi.nlm.nih.gov/pubmed/32498469
http://dx.doi.org/10.3390/molecules25112593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321065/
https://www.ncbi.nlm.nih.gov/pubmed/32498469
http://dx.doi.org/10.3390/molecules25112593

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