The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments

(−)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [(35)S]GTPγS binding, forskolin-induced cAMP accumulation assay, and MOR-mediated β-arrestin recruitment assays). “Body” a...

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Detalles Bibliográficos
Autores principales: Wang, Meining, Irvin, Thomas C., Herdman, Christine A., Hanna, Ramsey D., Hassan, Sergio A., Lee, Yong-Sok, Kaska, Sophia, Crowley, Rachel Saylor, Prisinzano, Thomas E., Withey, Sarah L., Paronis, Carol A., Bergman, Jack, Inan, Saadet, Geller, Ellen B., Adler, Martin W., Kopajtic, Theresa A., Katz, Jonathan L., Chadderdon, Aaron M., Traynor, John R., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321161/
https://www.ncbi.nlm.nih.gov/pubmed/32517185
http://dx.doi.org/10.3390/molecules25112640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321161/
https://www.ncbi.nlm.nih.gov/pubmed/32517185
http://dx.doi.org/10.3390/molecules25112640

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