Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics

Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several membrane proteins, including Rab and Endophilin, and has recently been...

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Detalles Bibliográficos
Autores principales: Sanstrum, Bethany J., Goo, Brandee M. S. S., Holden, Diana Z. Y., Delgado, Donovan D., Nguyen, Thien P. N., Lee, Kiana D., James, Nicholas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321188/
https://www.ncbi.nlm.nih.gov/pubmed/32486414
http://dx.doi.org/10.3390/molecules25112561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321188/
https://www.ncbi.nlm.nih.gov/pubmed/32486414
http://dx.doi.org/10.3390/molecules25112561

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