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Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics
Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several membrane proteins, including Rab and Endophilin, and has recently been...
Autores principales: | Sanstrum, Bethany J., Goo, Brandee M. S. S., Holden, Diana Z. Y., Delgado, Donovan D., Nguyen, Thien P. N., Lee, Kiana D., James, Nicholas G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321188/ https://www.ncbi.nlm.nih.gov/pubmed/32486414 http://dx.doi.org/10.3390/molecules25112561 |
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