Model Substrate/Inactivation Reactions for MoaA and Ribonucleotide Reductases: Loss of Bromo, Chloro, or Tosylate Groups from C2 of 1,5-Dideoxyhomoribofuranoses upon Generation of an α-Oxy Radical at C3 †

We report studies on radical-initiated fragmentations of model 1,5-dideoxyhomoribofuranose derivatives with bromo, chloro, and tosyloxy substituents on C2. The effects of stereochemical inversion at C2 were probed with the corresponding arabino epimers. In all cases, the elimination of bromide, chlo...

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Detalles Bibliográficos
Autores principales: Wnuk, Stanislaw F., Mudgal, Mukesh M., Nowak, Ireneusz, Robins, Morris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321198/
https://www.ncbi.nlm.nih.gov/pubmed/32486052
http://dx.doi.org/10.3390/molecules25112539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321198/
https://www.ncbi.nlm.nih.gov/pubmed/32486052
http://dx.doi.org/10.3390/molecules25112539

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