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Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of (99m)Tc-Tricarbonyl-Based Radiopharmaceuticals
The organometallic technetium-99m tricarbonyl core, [(99m)Tc][Tc(CO)(3)(H(2)O)(3)](+), is a versatile precursor for the development of radiotracers for single photon emission computed tomography (SPECT). A drawback of the (99m)Tc-tricarbonyl core is its lipophilicity, which can influence the pharmac...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321340/ https://www.ncbi.nlm.nih.gov/pubmed/32527027 http://dx.doi.org/10.3390/molecules25112680 |