RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit

The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic mechanism has not been well characterized. Phosphorylated level of RSK (T573) was increased in acute myeloid leukemia (AML) patients and associated with poor survival. To examine the role o...

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Detalles Bibliográficos
Autores principales: Chae, Hee-Don, Dutta, Ritika, Tiu, Bruce, Hoff, Fieke W., Accordi, Benedetta, Serafin, Valentina, Youn, Minyoung, Huang, Min, Sumarsono, Nathan, Davis, Kara L., Lacayo, Norman J., Pigazzi, Martina, Horton, Terzah M., Kornblau, Steven M., Sakamoto, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321696/
https://www.ncbi.nlm.nih.gov/pubmed/32637030
http://dx.doi.org/10.18632/oncotarget.27630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321696/
https://www.ncbi.nlm.nih.gov/pubmed/32637030
http://dx.doi.org/10.18632/oncotarget.27630

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