Cargando…

LEM2 phase separation governs ESCRT-mediated nuclear envelope reformation

During cell division, remodeling of the nuclear envelope (NE) enables chromosome segregation by the mitotic spindle(1). The reformation of sealed nuclei requires Endosomal Sorting Complexes Required for Transport (ESCRTs) and LEM2, a transmembrane ESCRT adapter(2–4). Here, we show how LEM2’s ability...

Descripción completa

Detalles Bibliográficos
Autores principales:	von Appen, Alexander, LaJoie, Dollie, Johnson, Isabel E., Trnka, Michael J., Pick, Sarah M., Burlingame, Alma L., Ullman, Katharine S., Frost, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321842/ https://www.ncbi.nlm.nih.gov/pubmed/32494070 http://dx.doi.org/10.1038/s41586-020-2232-x

Ejemplares similares

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
por: Gu, Mingyu, et al.
Publicado: (2017)

A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents
por: LaJoie, Dollie, et al.
Publicado: (2022)

ESCRT-III controls nuclear envelope reformation
por: Olmos, Yolanda, et al.
Publicado: (2015)

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system
por: Thaller, David J, et al.
Publicado: (2019)

The LEM-ESCRT toolkit: Repair and maintenance of the nucleus
por: Borah, Sapan, et al.
Publicado: (2022)

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation
por: Olmos, Yolanda, et al.
Publicado: (2016)

The nuclear envelope LEM-domain protein emerin
por: Berk, Jason M, et al.
Publicado: (2013)

Identification of the evolutionarily conserved nuclear envelope proteins Lem2 and MicLem2 in Tetrahymena thermophila
por: Iwamoto, Masaaki, et al.
Publicado: (2019)

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope
por: Ventimiglia, Leandro N., et al.
Publicado: (2018)

Loss of nuclear envelope integrity? No probLEM—BAF has it covered
por: King, Megan C., et al.
Publicado: (2019)

Phase Separation in the Nucleus and at the Nuclear Periphery during Post-Mitotic Nuclear Envelope Reformation
por: Maccaroni, Klizia, et al.
Publicado: (2022)

ESCRT-III controls nuclear envelope deformation induced by progerin
por: Arii, Jun, et al.
Publicado: (2020)

ESCRT-III/Vps4 Controls Heterochromatin-Nuclear Envelope Attachments
por: Pieper, Gerard H., et al.
Publicado: (2020)

Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway
por: Lee, I-Ju, et al.
Publicado: (2020)

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage
por: Willan, Jessica, et al.
Publicado: (2019)

Nuclear Envelope Protein Lem2 is Required for Mouse Development and Regulates MAP and AKT Kinases
por: Tapia, Olga, et al.
Publicado: (2015)

Heterogeneous Immunoreactivity of Emerin, a Nuclear Envelope LEM-domain Protein, in Normal Thyroid Follicles
por: Jieying, Wang, et al.
Publicado: (2014)

Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure
por: Penfield, Lauren, et al.
Publicado: (2020)

Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum
por: Hirano, Yasuhiro, et al.
Publicado: (2020)

Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure
por: Barger, Sarah R., et al.
Publicado: (2023)

Nuclear envelope assembly relies on CHMP-7 in the absence of BAF–LEM-mediated hole closure
por: Barger, Sarah R., et al.
Publicado: (2023)

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling
por: Lu, Michelle Seiko, et al.
Publicado: (2020)

ESCRT-III–mediated membrane fusion drives chromosome fragments through nuclear envelope channels
por: Warecki, Brandt, et al.
Publicado: (2020)

The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection
por: Ju, Yichen, et al.
Publicado: (2021)

Anisotropic ESCRT-III architecture governs helical membrane tube formation
por: Moser von Filseck, Joachim, et al.
Publicado: (2020)

Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations
por: Thaller, David J., et al.
Publicado: (2021)

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
por: Wallis, Samuel S., et al.
Publicado: (2021)

ESCRTs breach the nuclear border
por: Webster, Brant M, et al.
Publicado: (2015)

Insights into the function of ESCRT and its role in enveloped virus infection
por: Wang, Chunxuan, et al.
Publicado: (2023)

CDK1 controls CHMP7-dependent nuclear envelope reformation
por: Gatta, Alberto T, et al.
Publicado: (2021)

The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle
por: Meng, Bo, et al.
Publicado: (2021)

Lem2 is essential for cardiac development by maintaining nuclear integrity
por: Ross, Jacob A, et al.
Publicado: (2023)

Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase
por: Haraguchi, Tokuko, et al.
Publicado: (2022)

The Development of Criminal Style in Adolescence and Young Adulthood: Separating the Lemmings from the Loners
por: Goldweber, Asha, et al.
Publicado: (2010)

Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing
por: Strohacker, Lauren K, et al.
Publicado: (2021)

Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
por: Kume, Kazunori, et al.
Publicado: (2019)

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
por: Martín Caballero, Lucía, et al.
Publicado: (2022)

Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2
por: Barrales, Ramón Ramos, et al.
Publicado: (2016)

HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β
por: Tawara, Ken, et al.
Publicado: (2019)

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission
por: Wenzel, Dawn M, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1rvcs3v0944t120oc1tc0l2eh5