cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Because raising cAMP enhances 26S proteasome activity and the degradation of cell proteins, including the selective breakdown of misfolded proteins, we investigated whether agents that raise cGMP may also regulate protein degradation. Treating various cell lines with inhibitors of phosphodiesterase...

Descripción completa

Detalles Bibliográficos
Autores principales: VerPlank, Jordan J. S., Tyrkalska, Sylwia D., Fleming, Angeleen, Rubinsztein, David C., Goldberg, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321992/
https://www.ncbi.nlm.nih.gov/pubmed/32513741
http://dx.doi.org/10.1073/pnas.2003277117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321992/
https://www.ncbi.nlm.nih.gov/pubmed/32513741
http://dx.doi.org/10.1073/pnas.2003277117

Ejemplares similares