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Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters

The mechanisms by which methylated mammalian promoters are transcriptionally silenced even in the presence of all of the factors required for their expression have long been a major unresolved issue in the field of epigenetics. Repression requires the assembly of a methylation-dependent silencing co...

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Detalles Bibliográficos
Autores principales: Boulard, Mathieu, Rucli, Sofia, Edwards, John R., Bestor, Timothy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322000/
https://www.ncbi.nlm.nih.gov/pubmed/32522876
http://dx.doi.org/10.1073/pnas.1912074117