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Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein
The interaction of the neuronal protein α-synuclein with lipid membranes appears crucial in the context of Parkinson’s disease, but the underlying mechanistic details, including the roles of different lipids in pathogenic protein aggregation and membrane disruption, remain elusive. Here, we used sin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322013/ https://www.ncbi.nlm.nih.gov/pubmed/32513706 http://dx.doi.org/10.1073/pnas.1914670117 |