Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding

OBJECTIVE: Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiting glucose-stimulated insulin secretion (GSIS), potentially involving remodelling of cellular lipids, have been suggested from in vitro studies but not evaluated in vivo....

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Detalles Bibliográficos
Autores principales: Chu, Kwan Yi, Mellet, Natalie, Thai, Le May, Meikle, Peter J., Biden, Trevor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322075/
https://www.ncbi.nlm.nih.gov/pubmed/32504884
http://dx.doi.org/10.1016/j.molmet.2020.101023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322075/
https://www.ncbi.nlm.nih.gov/pubmed/32504884
http://dx.doi.org/10.1016/j.molmet.2020.101023

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