O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity

The Hippo pathway controls organ size and tissue homeostasis by regulating cell proliferation and apoptosis. The LATS-mediated negative feedback loop prevents excessive activation of the effectors YAP/TAZ, maintaining homeostasis of the Hippo pathway. YAP and TAZ are hyperactivated in various cancer...

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Detalles Bibliográficos
Autores principales: Kim, Eunah, Kang, Jeong Gu, Kang, Min Jueng, Park, Jae Hyung, Kim, Yeon Jung, Kweon, Tae Hyun, Lee, Han-Woong, Jho, Eek‐hoon, Lee, Yong-ho, Kim, Seung-Il, Yi, Eugene C., Park, Hyun Woo, Yang, Won Ho, Cho, Jin Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322088/
https://www.ncbi.nlm.nih.gov/pubmed/32513743
http://dx.doi.org/10.1073/pnas.1913469117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322088/
https://www.ncbi.nlm.nih.gov/pubmed/32513743
http://dx.doi.org/10.1073/pnas.1913469117

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