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Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their abilit...

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Autores principales: Brufsky, Adam, Marti, Juan Luis Gomez, Nasrazadani, Azadeh, Lotze, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322393/
https://www.ncbi.nlm.nih.gov/pubmed/32600410
http://dx.doi.org/10.1186/s12967-020-02433-6
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author Brufsky, Adam
Marti, Juan Luis Gomez
Nasrazadani, Azadeh
Lotze, Michael T.
author_facet Brufsky, Adam
Marti, Juan Luis Gomez
Nasrazadani, Azadeh
Lotze, Michael T.
author_sort Brufsky, Adam
collection PubMed
description Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered.
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spelling pubmed-73223932020-06-29 Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection Brufsky, Adam Marti, Juan Luis Gomez Nasrazadani, Azadeh Lotze, Michael T. J Transl Med Review Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered. BioMed Central 2020-06-29 /pmc/articles/PMC7322393/ /pubmed/32600410 http://dx.doi.org/10.1186/s12967-020-02433-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Brufsky, Adam
Marti, Juan Luis Gomez
Nasrazadani, Azadeh
Lotze, Michael T.
Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title_full Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title_fullStr Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title_full_unstemmed Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title_short Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
title_sort boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322393/
https://www.ncbi.nlm.nih.gov/pubmed/32600410
http://dx.doi.org/10.1186/s12967-020-02433-6
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