Cargando…
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design
Natural evolution has generated an impressively diverse protein universe via duplication and recombination from a set of protein fragments that served as building blocks. The application of these concepts to the design of new proteins using subdomain-sized fragments from different folds has proven t...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322520/ https://www.ncbi.nlm.nih.gov/pubmed/32330481 http://dx.doi.org/10.1016/j.jmb.2020.04.013 |