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Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design

Natural evolution has generated an impressively diverse protein universe via duplication and recombination from a set of protein fragments that served as building blocks. The application of these concepts to the design of new proteins using subdomain-sized fragments from different folds has proven t...

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Detalles Bibliográficos
Autores principales: Ferruz, Noelia, Lobos, Francisco, Lemm, Dominik, Toledo-Patino, Saacnicteh, Farías-Rico, José Arcadio, Schmidt, Steffen, Höcker, Birte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322520/
https://www.ncbi.nlm.nih.gov/pubmed/32330481
http://dx.doi.org/10.1016/j.jmb.2020.04.013