Cargando…

Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design

Natural evolution has generated an impressively diverse protein universe via duplication and recombination from a set of protein fragments that served as building blocks. The application of these concepts to the design of new proteins using subdomain-sized fragments from different folds has proven t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferruz, Noelia, Lobos, Francisco, Lemm, Dominik, Toledo-Patino, Saacnicteh, Farías-Rico, José Arcadio, Schmidt, Steffen, Höcker, Birte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322520/ https://www.ncbi.nlm.nih.gov/pubmed/32330481 http://dx.doi.org/10.1016/j.jmb.2020.04.013

Ejemplares similares

Fuzzle 2.0: Ligand Binding in Natural Protein Building Blocks
por: Ferruz, Noelia, et al.
Publicado: (2021)

ProteinTools: a toolkit to analyze protein structures
por: Ferruz, Noelia, et al.
Publicado: (2021)

ProtGPT2 is a deep unsupervised language model for protein design
por: Ferruz, Noelia, et al.
Publicado: (2022)

Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor
por: Toledo-Patiño, Saacnicteh, et al.
Publicado: (2019)

Protlego: a Python package for the analysis and design of chimeric proteins
por: Ferruz, Noelia, et al.
Publicado: (2021)

PocketOptimizer 2.0: A modular framework for computer‐aided ligand‐binding design
por: Noske, Jakob, et al.
Publicado: (2023)

Insertions and deletions mediated functional divergence of Rossmann fold enzymes
por: Toledo-Patiño, Saacnicteh, et al.
Publicado: (2022)

A Short Tale of the Origin of Proteins and Ribosome Evolution
por: Farías-Rico, José Arcadio, et al.
Publicado: (2022)

Implications of divergence of methionine adenosyltransferase in archaea
por: Chouhan, Bhanu Pratap Singh, et al.
Publicado: (2021)

Folding and Evolution of a Repeat Protein on the Ribosome
por: León-González, José Alberto, et al.
Publicado: (2022)

Retracing the evolution of a modern periplasmic binding protein
por: Michel, Florian, et al.
Publicado: (2023)

Nature's building blocks: an A-Z guide to the elements
por: Emsley, John
Publicado: (2001)

Evolution, folding, and design of TIM barrels and related proteins
por: Romero-Romero, Sergio, et al.
Publicado: (2021)

Isotopic evolution of the protoplanetary disk and the building blocks of Earth and Moon
por: Schiller, Martin, et al.
Publicado: (2018)

Tetracarbonatodiruthenium Fragments and Lanthanide(III) Ions as Building Blocks to Construct 2D Coordination Polymers
por: Gutiérrez-Martín, Daniel, et al.
Publicado: (2019)

Electrochemical synthesis of biobased polymers and polymer building blocks from vanillin
por: Kunkel, Robin, et al.
Publicado: (2021)

Cobaloximes as Building Blocks in Halogen-Bonded Cocrystals
por: Bedeković, Nikola, et al.
Publicado: (2020)

The building blocks
Publicado: (2008)

Culture’s building blocks: investigating cultural evolution in a LEGO construction task
por: McGraw, John J., et al.
Publicado: (2014)

Carbene derived diradicaloids – building blocks for singlet fission?
por: Messelberger, Julian, et al.
Publicado: (2018)

Building blocks for social accountability: a conceptual framework to guide medical schools
por: Preston, Robyn, et al.
Publicado: (2016)

Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme
por: Ferruz, Noelia, et al.
Publicado: (2016)

Statistical Analysis and Tokenization of Epitopes to Construct Artificial Neoepitope Libraries
por: Lopez-Martinez, Elena, et al.
Publicado: (2023)

Building Blocks of the Universe
por: The ATLAS collaboration
Publicado: (2015)

SPB building blocks
por: Wells, William A.
Publicado: (2006)

Fluorinated azobenzenes as supramolecular halogen-bonding building blocks
por: Nieland, Esther, et al.
Publicado: (2019)

The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
por: Yang, Xiaohan, et al.
Publicado: (2017)

From sequence to function through structure: Deep learning for protein design
por: Ferruz, Noelia, et al.
Publicado: (2022)

Looking for the Universe's building blocks
por: Schlein, L
Publicado: (2001)

Building blocks for topology change
por: Alty, L J
Publicado: (1994)

In search of the ultimate building blocks
por: 't Hooft, Gerardus
Publicado: (1997)

Modeling the Building Blocks of Biodiversity
por: Joppa, Lucas N., et al.
Publicado: (2013)

The building blocks of social communication
por: Niznikiewicz, Margaret A.
Publicado: (2013)

The Building Blocks of Integrated Care
por: Kaehne, Axel
Publicado: (2016)

Nitroxides as Building Blocks for Nanoantioxidants
por: Genovese, Damiano, et al.
Publicado: (2021)

The Building Blocks of Architecture and Mathematics
por: Williams, Kim
Publicado: (2021)

Discovering feature relevancy and dependency by kernel-guided probabilistic model-building evolution
por: Rodriguez, Nestor, et al.
Publicado: (2017)

Building blocks for automated elucidation of metabolites: Machine learning methods for NMR prediction
por: Kuhn, Stefan, et al.
Publicado: (2008)

ColorEM: analytical electron microscopy for element-guided identification and imaging of the building blocks of life
por: Pirozzi, Nicole M., et al.
Publicado: (2018)

Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking
por: Metz, Alexander, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l5ne2fa07nqcsgl25tau26phu1