Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in...

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Detalles Bibliográficos
Autores principales: Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322544/
https://www.ncbi.nlm.nih.gov/pubmed/31981640
http://dx.doi.org/10.1016/j.taap.2020.114883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322544/
https://www.ncbi.nlm.nih.gov/pubmed/31981640
http://dx.doi.org/10.1016/j.taap.2020.114883

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