Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons

Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the most important genetic risk factor for Parkinson disease (PD). GCase activity is also decreased in sporadic PD brains and with normal ageing. Loss of GCase activity impairs the autophagy lysosomal pathw...

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Detalles Bibliográficos
Autores principales: Gegg, Matthew E, Verona, Guglielmo, Schapira, Anthony H V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322566/
https://www.ncbi.nlm.nih.gov/pubmed/32391886
http://dx.doi.org/10.1093/hmg/ddaa085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322566/
https://www.ncbi.nlm.nih.gov/pubmed/32391886
http://dx.doi.org/10.1093/hmg/ddaa085

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