Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

OBJECTIVES: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). METHODS: Female mice expressing the Ca(2+) indicator GCaMP3 specifically in alpha-cells were f...

Descripción completa

Detalles Bibliográficos
Autores principales: Kellard, Joely A., Rorsman, Nils J.G., Hill, Thomas G., Armour, Sarah L., van de Bunt, Martijn, Rorsman, Patrik, Knudsen, Jakob G., Briant, Linford J.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322681/
https://www.ncbi.nlm.nih.gov/pubmed/32446876
http://dx.doi.org/10.1016/j.molmet.2020.101021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322681/
https://www.ncbi.nlm.nih.gov/pubmed/32446876
http://dx.doi.org/10.1016/j.molmet.2020.101021

Ejemplares similares