Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain

BACKGROUND: Paclitaxel is an important chemotherapeutic agent for the treatment of breast cancer. Paclitaxel-induced peripheral neuropathy (PIPN) is a major dose-limiting toxicity that can persist into survivorship. While not all survivors develop PIPN, for those who do, it has a substantial negativ...

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Detalles Bibliográficos
Autores principales: Kober, Kord M, Lee, Man-Cheung, Olshen, Adam, Conley, Yvette P, Sirota, Marina, Keiser, Michael, Hammer, Marilyn J, Abrams, Gary, Schumacher, Mark, Levine, Jon D, Miaskowski, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322824/
https://www.ncbi.nlm.nih.gov/pubmed/32586194
http://dx.doi.org/10.1177/1744806920936502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322824/
https://www.ncbi.nlm.nih.gov/pubmed/32586194
http://dx.doi.org/10.1177/1744806920936502

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