Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men
PURPOSE: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training coul...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322975/ https://www.ncbi.nlm.nih.gov/pubmed/32612355 http://dx.doi.org/10.2147/CIA.S248868 |
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author | Kemmler, Wolfgang von Stengel, Simon Kohl, Matthias Rohleder, Nicolas Bertsch, Thomas Sieber, Cornel C Freiberger, Ellen Kob, Robert |
author_facet | Kemmler, Wolfgang von Stengel, Simon Kohl, Matthias Rohleder, Nicolas Bertsch, Thomas Sieber, Cornel C Freiberger, Ellen Kob, Robert |
author_sort | Kemmler, Wolfgang |
collection | PubMed |
description | PURPOSE: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training could potentially lead to deteriorations of the cardiac as well as the renal function. MATERIALS AND METHODS: One hundred sarcopenic obese men aged 70 years and older were randomly balanced (1-1-1) and allocated to one of the three study arms. During 16 weeks of intervention, these groups either performed WB-EMS and took a protein supplement (WB-EMS&P), solely received the protein supplement (Protein) or served as control group (CG). WB-EMS consisted of 1.5×20 min (85 Hz, 350 μs, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7–1.8 g/kg/body mass per day. At baseline and 8–10 days after completion of the intervention, blood was drawn and biomarkers of muscle, cardiac and renal health were assessed. RESULTS: Hereby, we found slight but significant elevations of creatine kinase (CK) levels in the WB-EMS group pointing to minor damages of the skeletal muscle (140 U/l [81–210], p < 0.001). This was accompanied by a significant, low-grade increase of creatine kinase–muscle brain (CK-MB, 0.43 ng/mL [−0.29–0.96], p < 0.01) and high-sensitivity troponin T (hsTnT, 0.001 ng/mL. [0.000–0.003], p < 0.001) but without a higher risk of developing heart failure according to N-terminal prohormone of brain natriuretic peptide (NT-proBNP, −5.7 pg/mL [−38.8–24.6], p = 0.17). Estimated glomerular filtration rate (eGFR) was impaired neither by the high-protein supplementation alone nor in combination with WB-EMS (CG 76.0 mL/min/1.73 m(2) [71.9–82.2] vs Protein 73.2 mL/min/1.73 m(2) [63.0–78.9] vs WB-EMS&P 74.6 mL/min/1.73 m(2) [62.8–84.1], p = 0.478). CONCLUSION: In conclusion, even in the vulnerable group of sarcopenic obese seniors, the combination of WB-EMS with a high-protein intake revealed no short-term, negative impact on the eGFR, but potential consequences for the cardiovascular system need to be addressed in future studies. |
format | Online Article Text |
id | pubmed-7322975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-73229752020-06-30 Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men Kemmler, Wolfgang von Stengel, Simon Kohl, Matthias Rohleder, Nicolas Bertsch, Thomas Sieber, Cornel C Freiberger, Ellen Kob, Robert Clin Interv Aging Original Research PURPOSE: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training could potentially lead to deteriorations of the cardiac as well as the renal function. MATERIALS AND METHODS: One hundred sarcopenic obese men aged 70 years and older were randomly balanced (1-1-1) and allocated to one of the three study arms. During 16 weeks of intervention, these groups either performed WB-EMS and took a protein supplement (WB-EMS&P), solely received the protein supplement (Protein) or served as control group (CG). WB-EMS consisted of 1.5×20 min (85 Hz, 350 μs, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7–1.8 g/kg/body mass per day. At baseline and 8–10 days after completion of the intervention, blood was drawn and biomarkers of muscle, cardiac and renal health were assessed. RESULTS: Hereby, we found slight but significant elevations of creatine kinase (CK) levels in the WB-EMS group pointing to minor damages of the skeletal muscle (140 U/l [81–210], p < 0.001). This was accompanied by a significant, low-grade increase of creatine kinase–muscle brain (CK-MB, 0.43 ng/mL [−0.29–0.96], p < 0.01) and high-sensitivity troponin T (hsTnT, 0.001 ng/mL. [0.000–0.003], p < 0.001) but without a higher risk of developing heart failure according to N-terminal prohormone of brain natriuretic peptide (NT-proBNP, −5.7 pg/mL [−38.8–24.6], p = 0.17). Estimated glomerular filtration rate (eGFR) was impaired neither by the high-protein supplementation alone nor in combination with WB-EMS (CG 76.0 mL/min/1.73 m(2) [71.9–82.2] vs Protein 73.2 mL/min/1.73 m(2) [63.0–78.9] vs WB-EMS&P 74.6 mL/min/1.73 m(2) [62.8–84.1], p = 0.478). CONCLUSION: In conclusion, even in the vulnerable group of sarcopenic obese seniors, the combination of WB-EMS with a high-protein intake revealed no short-term, negative impact on the eGFR, but potential consequences for the cardiovascular system need to be addressed in future studies. Dove 2020-06-24 /pmc/articles/PMC7322975/ /pubmed/32612355 http://dx.doi.org/10.2147/CIA.S248868 Text en © 2020 Kemmler et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Kemmler, Wolfgang von Stengel, Simon Kohl, Matthias Rohleder, Nicolas Bertsch, Thomas Sieber, Cornel C Freiberger, Ellen Kob, Robert Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title | Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title_full | Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title_fullStr | Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title_full_unstemmed | Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title_short | Safety of a Combined WB-EMS and High-Protein Diet Intervention in Sarcopenic Obese Elderly Men |
title_sort | safety of a combined wb-ems and high-protein diet intervention in sarcopenic obese elderly men |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322975/ https://www.ncbi.nlm.nih.gov/pubmed/32612355 http://dx.doi.org/10.2147/CIA.S248868 |
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