Accurately Reflecting Uncertainty When Using Patient-Level Simulation Models to Extrapolate Clinical Trial Data

Introduction. Patient-level simulation models facilitate extrapolation of clinical trial data while allowing for heterogeneity, prior history, and nonlinearity. However, combining different types of uncertainty around within-trial and extrapolated results remains challenging. Methods. We tested 4 me...

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Detalles Bibliográficos
Autores principales: Dakin, Helen A., Leal, José, Briggs, Andrew, Clarke, Philip, Holman, Rury R., Gray, Alastair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323001/
https://www.ncbi.nlm.nih.gov/pubmed/32431211
http://dx.doi.org/10.1177/0272989X20916442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323001/
https://www.ncbi.nlm.nih.gov/pubmed/32431211
http://dx.doi.org/10.1177/0272989X20916442

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