Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

BACKGROUND: Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of intermediate states in the catalytic process. Previous work on the subtilisin protease,...

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Detalles Bibliográficos
Autores principales: Wu, Shanshan, Nguyen, Tam T.T.N., Moroz, Olga V., Turkenburg, Johan P., Nielsen, Jens E., Wilson, Keith S., Rand, Kasper D., Teilum, Kaare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323712/
https://www.ncbi.nlm.nih.gov/pubmed/32617193
http://dx.doi.org/10.7717/peerj.9408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323712/
https://www.ncbi.nlm.nih.gov/pubmed/32617193
http://dx.doi.org/10.7717/peerj.9408

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