Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production

A large group of biopharmaceuticals is produced in cell lines. The yield of such products can be increased by genetic engineering of the corresponding cell lines. The prediction of promising genetic modifications by mathematical modeling is a valuable tool to facilitate experimental screening. Besid...

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Detalles Bibliográficos
Autores principales: Duvigneau, Stefanie, Dürr, Robert, Laske, Tanja, Bachmann, Mandy, Dostert, Melanie, Kienle, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323952/
https://www.ncbi.nlm.nih.gov/pubmed/32598363
http://dx.doi.org/10.1371/journal.pcbi.1007810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323952/
https://www.ncbi.nlm.nih.gov/pubmed/32598363
http://dx.doi.org/10.1371/journal.pcbi.1007810

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