Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity

Molecules that correct the folding of protein mutants, restoring their functional trafficking, are called pharmacoperones. Most are clinically irrelevant and possess intrinsic antagonist or agonist activity. Here, we identify compounds capable of rescuing the activity of mutant gonadotropin-releasin...

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Detalles Bibliográficos
Autores principales: Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324376/
https://www.ncbi.nlm.nih.gov/pubmed/32601341
http://dx.doi.org/10.1038/s41598-020-67473-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324376/
https://www.ncbi.nlm.nih.gov/pubmed/32601341
http://dx.doi.org/10.1038/s41598-020-67473-w

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