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Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
Molecules that correct the folding of protein mutants, restoring their functional trafficking, are called pharmacoperones. Most are clinically irrelevant and possess intrinsic antagonist or agonist activity. Here, we identify compounds capable of rescuing the activity of mutant gonadotropin-releasin...
Autores principales: | Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324376/ https://www.ncbi.nlm.nih.gov/pubmed/32601341 http://dx.doi.org/10.1038/s41598-020-67473-w |
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