Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study

Thiosemicarbazones (TSC) and their metal complexes display diverse biological activities and are active against multiple pathological conditions ranging from microbial infections to abnormal cell proliferation. Ribonucleotide reductase (RNR) is considered one of the main targets of TSCs, yet, the ex...

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Detalles Bibliográficos
Autores principales: Baruffini, Enrico, Ruotolo, Roberta, Bisceglie, Franco, Montalbano, Serena, Ottonello, Simone, Pelosi, Giorgio, Buschini, Annamaria, Lodi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324377/
https://www.ncbi.nlm.nih.gov/pubmed/32601343
http://dx.doi.org/10.1038/s41598-020-67439-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324377/
https://www.ncbi.nlm.nih.gov/pubmed/32601343
http://dx.doi.org/10.1038/s41598-020-67439-y

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