Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader

PURPOSE: Preclinical in vivo nuclear imaging of mice offers an enabling perspective to evaluate drug efficacy at optimal dose and schedule. In this study, we interrogated sufficient estrogen receptor occupancy and degradation for the selective estrogen receptor degrader (SERD) compound SAR439859 usi...

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Detalles Bibliográficos
Autores principales: Besret, Laurent, d’Heilly, Sébastien, Aubert, Cathy, Bluet, Guillaume, Gruss-Leleu, Florence, Le-Gall, Françoise, Caron, Anne, Andrieu, Laurent, Vincent, Sylvie, Shomali, Maysoun, Bouaboula, Monsif, Voland, Carole, Ming, Jeffrey, Roy, Sébastien, Rao, Srinivas, Carrez, Chantal, Jouannot, Erwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324464/
https://www.ncbi.nlm.nih.gov/pubmed/32601772
http://dx.doi.org/10.1186/s13550-020-00646-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324464/
https://www.ncbi.nlm.nih.gov/pubmed/32601772
http://dx.doi.org/10.1186/s13550-020-00646-w

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