A novel protective role for microRNA-3135b in Golgi apparatus fragmentation induced by chemotherapy via GOLPH3/AKT1/mTOR axis in colorectal cancer cells

Chemotherapy activates a novel cytoplasmic DNA damage response resulting in Golgi apparatus fragmentation and cancer cell survival. This mechanism is regulated by Golgi phosphoprotein-3 (GOLPH3)/Myo18A/F-actin axis. Analyzing the functions of miR-3135b, a small non-coding RNA with unknown functions,...

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Detalles Bibliográficos
Autores principales: Núñez-Olvera, Stephanie I., Chávez-Munguía, Bibiana, del Rocío Terrones-Gurrola, María Cruz, Marchat, Laurence A., Puente-Rivera, Jonathan, Ruíz-García, Erika, Campos-Parra, Alma D., Vázquez-Calzada, Carlos, Lizárraga-Verdugo, Erik R., Ramos-Payán, Rosalío, Salinas-Vera, Yarely M., López-Camarillo, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324564/
https://www.ncbi.nlm.nih.gov/pubmed/32601379
http://dx.doi.org/10.1038/s41598-020-67550-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324564/
https://www.ncbi.nlm.nih.gov/pubmed/32601379
http://dx.doi.org/10.1038/s41598-020-67550-0

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