In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents

The cytotoxic mechanism of the saponin QS-21 and its aglycone quillaic acid (QA) was studied on human gastric cancer cells (SNU1 and KATO III). Both compounds showed in vitro cytotoxic activity with IC(50) values: 7.1 μM (QS-21) and 13.6 μM (QA) on SNU1 cells; 7.4 μM (QS-21) and 67 μM (QA) on KATO I...

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Detalles Bibliográficos
Autores principales: Guzmán, Leda, Villalón, Katherine, Marchant, María José, Tarnok, María Elena, Cárdenas, Pilar, Aquea, Gisela, Acevedo, Waldo, Padilla, Leandro, Bernal, Giuliano, Molinari, Aurora, Corvalán, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324585/
https://www.ncbi.nlm.nih.gov/pubmed/32601436
http://dx.doi.org/10.1038/s41598-020-67442-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324585/
https://www.ncbi.nlm.nih.gov/pubmed/32601436
http://dx.doi.org/10.1038/s41598-020-67442-3

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