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Impact of Data Preprocessing on Integrative Matrix Factorization of Single Cell Data

Integrative, single-cell analyses may provide unprecedented insights into cellular and spatial diversity of the tumor microenvironment. The sparsity, noise, and high dimensionality of these data present unique challenges. Whilst approaches for integrating single-cell data are emerging and are far fr...

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Detalles Bibliográficos
Autores principales: Hsu, Lauren L., Culhane, Aedin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324639/
https://www.ncbi.nlm.nih.gov/pubmed/32656082
http://dx.doi.org/10.3389/fonc.2020.00973